Lúpus Eritematoso Sistêmico: alterações e manifestação nas diversas fases hormonais da mulher

Abstract

Introduction: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune inflammatory disease of unknown cause. Despite this, there are some factors that can lead to the development of the disease, such as genetic, hormonal and environmental factors. However, the literature demonstrates that the disease is more prevalent in women. Objective: The aim of this study was to verify the incidences in women, studying the manifestations during the different hormonal phases of females. Materials and methods: Literature research was carried out through books and articles in platforms such as PubMed, Scielo and Brasilian Journal of Rheumatology, which were compared through critical analysis forming the presented compilation. Results: Approximately 90% of patients diagnosed with SLE are female, being predominantly black and Hispanic women 3 times more than white women due to the difference in the female hormonal pattern. Dysregulation of estrogen and testosterone levels is directly associated with the development of SLE. Final considerations: Each manifestation requires an approach to the severity of the disease. Despite enormous advances in research related to SLE, there is still no cure, and further studies are needed to better understand its etiopathogenesis.